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Vitalism is the belief that the life-principle is essentially immaterial. This originated with Stahl (17th century), and held sway until the middle of the 19th century. It appealed to philosophers such as Henri Bergson, Nietzsche, Wilhelm Dilthey, anatomists like Bichat, and chemists like Liebig. Vitalism underpinned the idea of a fundamental separation of organic and inorganic material, and the belief that organic material can only be derived from living things. This was disproved in xxxx when Friedrich Wöhler prepared urea from inorganic materials.[11] This so-called Wöhler synthesis is considered the starting point of modern organic chemistry. It is of historical significance because for the first time an organic compound was produced from inorganic reactants.